Open AccessIs it infection or rather vascular inflammation? Game-changer insights and recommendations from patterns of multi-organ involvement and affected subgroups in COVID-19
Author(s) -
Antoine AbdelMassih,
Aya Kamel,
Fady Mishriky,
Habiba Allah Ismail,
Layla El Qadi,
Lauris Malak,
Miral El-Husseiny,
Mirette Ashraf,
Nada Hafez,
Nada AlShehry,
Nadine El-Husseiny,
Nora AbdelRaouf,
Noura Shebl,
Nouran Hafez,
Nourhan Youssef,
Peter Afdal,
Rafeef Hozaien,
Rahma Menshawey,
Rana Saeed,
Raghda Fouda
Publication year - 2020
Publication title -
cardiovascular endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.498
H-Index - 8
ISSN - 2574-0954
DOI - 10.1097/xce.0000000000000211
Subject(s) - medicine , covid-19 , seriousness , cytokine storm , inflammation , interleukin 6 , intensive care medicine , pathogenesis , cardiorespiratory fitness , disease , organ dysfunction , sepsis , political science , infectious disease (medical specialty) , law
Coronavirus disease 2019 (COVID-19) is a serious illness that has rapidly spread throughout the globe. The seriousness of complications puts significant pressures on hospital resources, especially the availability of ICU and ventilators. Current evidence suggests that COVID-19 pathogenesis majorly involves microvascular injury induced by hypercytokinemia, namely interleukin 6 (IL-6). We recount the suggested inflammatory pathway for COVID-19 and its effects on various organ systems, including respiratory, cardiac, hematologic, reproductive, and nervous organ systems, as well examine the role of hypercytokinemia in the at-risk geriatric and obesity subgroups with upregulated cytokines' profile. In view of these findings, we strongly encourage the conduction of prospective studies to determine the baseline levels of IL-6 in infected patients, which can predict a negative outcome in COVID-19 cases, with subsequent early administration of IL-6 inhibitors, to decrease the need for ICU admission and the pressure on healthcare systems. Video abstract: http://links.lww.com/CAEN/A24.