Open AccessRecombinant human erythropoietin protects long-term cultured ageing primary nerve cells by upregulating the PI3K/Akt pathway
Author(s) -
Huqing Wang,
Ming Chen,
Zhen Gao,
Yu Gong,
Xiaorui Yu,
Haiqin Wu
Publication year - 2022
Publication title -
neuroreport/neuroreport
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.607
H-Index - 188
eISSN - 1473-558X
pISSN - 0959-4965
DOI - 10.1097/wnr.0000000000001768
Subject(s) - protein kinase b , pi3k/akt/mtor pathway , erythropoietin receptor , microbiology and biotechnology , erythropoietin , biology , ly294002 , western blot , apoptosis , signal transduction , chemistry , endocrinology , biochemistry , gene
Previous studies have found that recombinant human erythropoietin (rhEPO) protects long-term cultured ageing primary nerve cells by enhancing the endogenous antioxidant capacity of cells; however, its signalling pathways are not clear. This study aimed to explore the relationship between the rhEPO and PI3K/Akt pathways in the protection of senescent nerve cells at the cellular level.