Open AccessA new nitronyl nitroxide radical with salicylic acid framework attenuates blood–brain barrier disruption and oxidative stress in a rat model of middle cerebral artery occlusion
Author(s) -
Lei Chen,
Shengming Ma,
Min Shi,
Qiaofeng Wang,
Yifei Miao
Publication year - 2022
Publication title -
neuroreport/neuroreport
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.607
H-Index - 188
eISSN - 1473-558X
pISSN - 0959-4965
DOI - 10.1097/wnr.0000000000001764
Subject(s) - malondialdehyde , oxidative stress , neuroprotection , superoxide dismutase , glutathione peroxidase , pharmacology , reactive oxygen species , chemistry , ischemia , anesthesia , glutathione , medicine , reperfusion injury , endocrinology , biochemistry , enzyme
A new nitronyl nitroxide radical with a salicylic acid framework (SANR) has been demonstrated to exert antioxidant effects in the previous study by our team. The current study has assessed the protective effect of SANR on cerebral ischemia and reperfusion (I/R) in rat models.