Open AccessNBTI attenuates neuroinflammation and apoptosis partly by ENT1/NLRP3/Bcl2 pathway after subarachnoid hemorrhage in rats
Author(s) -
Xiaowei Chen,
Xiaocheng Luo,
Luyi Sun,
Qianghua Xu
Publication year - 2021
Publication title -
neuroreport/neuroreport
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.607
H-Index - 188
eISSN - 1473-558X
pISSN - 0959-4965
DOI - 10.1097/wnr.0000000000001733
Subject(s) - neuroinflammation , medicine , apoptosis , pharmacology , subarachnoid hemorrhage , inflammation , traumatic brain injury , microglia , neuroprotection , anesthesia , pathology , biology , biochemistry , psychiatry
Neuroinflammation and apoptosis are two key factors contributing to early brain injury (EBI) after subarachnoid hemorrhage (SAH) and are strongly associated with a poor prognosis. Recently, equilibrative nucleoside transporter 1 (ENT1) was emerged to accelerate the severity of inflammation and cell apoptosis in several nervous system diseases, including cerebral ischemia, neurodegeneration and epilepsy. However, no study has yet elaborated the expression levels and effects of ENT1 in EBI after SAH.