Open AccessDecreased spasticity of Baishaoluoshi Decoction through the BDNF/TrKB-KCC2 pathway on poststroke spasticity rats
Author(s) -
Liangdi Xie,
Youhua Xie,
Guo Mao,
Siyang Cao,
Rui Fang,
Zhou Songyang,
Junlin Jiang,
Ting Yao,
Jie Fan,
Liu Dong,
Dahua Wu,
Jinwen Ge
Publication year - 2021
Publication title -
neuroreport/neuroreport
Language(s) - English
Resource type - Journals
eISSN - 1473-558X
pISSN - 0959-4965
DOI - 10.1097/wnr.0000000000001709
Subject(s) - spasticity , medicine , decoction , stroke (engine) , tropomyosin receptor kinase b , neuroscience , neuroprotection , brainstem , anesthesia , pharmacology , neurotrophic factors , psychology , receptor , mechanical engineering , engineering
K+-Cl- cotransporter-2 (KCC2), which primarily extrudes chloride in mature neurons, triggers hemiplegia limb spasticity after ischemic stroke by affecting neuronal excitability. Our previous study revealed that the Chinese herb Baishaoluoshi Decoction decreases hemiplegia limb spasticity in poststroke spasticity (PSS) patients. This study aimed at elucidating on the effects of Baishaoluoshi Decoction on the BDNF/TrKB-KCC2 pathway in PSS rat models.