Open AccessNinjin’yoeito, a traditional Japanese Kampo medicine, suppresses the onset of anhedonia induced by dysfunction in the striatal dopamine receptor type 2-expressing medium spiny neurons
Author(s) -
Hiroaki Oizumi,
Ryota Imai,
T. Suzuki,
Yuji Omiya,
Kenji F. Tanaka,
Masaru Mimura,
Kazuo Mizoguchi
Publication year - 2021
Publication title -
neuroreport/neuroreport
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.607
H-Index - 188
eISSN - 1473-558X
pISSN - 0959-4965
DOI - 10.1097/wnr.0000000000001667
Subject(s) - anhedonia , striatum , dopamine , neurodegeneration , neuroscience , psychology , medium spiny neuron , dopaminergic , endocrinology , medicine , disease
Recent studies have suggested that ninjin'yoeito (NYT), a traditional Japanese Kampo medicine, improves diminished motivation in humans and animals, rendering it a novel therapeutic option for impaired motivation. To better characterize the effect of NYT on motivation, we examined its effect on motivated behaviors in mice.