Open AccessEffects of donepezil on the amplitude of low-frequency fluctuations in the brain of patients with Alzheimer’s disease: evidence from resting-state functional magnetic resonance imaging
Author(s) -
Hua Yang,
Jiangtao Zhang,
Jianan Cheng
Publication year - 2021
Publication title -
neuroreport/neuroreport
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.607
H-Index - 188
eISSN - 1473-558X
pISSN - 0959-4965
DOI - 10.1097/wnr.0000000000001659
Subject(s) - donepezil , resting state fmri , superior frontal gyrus , frontal lobe , medicine , dementia , clinical dementia rating , psychology , alzheimer's disease , mini–mental state examination , cardiology , magnetic resonance imaging , audiology , temporal lobe , functional magnetic resonance imaging , neuroscience , disease , radiology , epilepsy
To monitor the effects of donepezil on spontaneous neuronal activity (SNA), and the mechanisms underlying these effects in patients with mild-to-moderate Alzheimer's disease, using the amplitude of low-frequency fluctuations (ALFFs), a metric of resting-state functional MRI (rs-fMRI).