Open AccessVitamin K2 protects against Aβ42-induced neurotoxicity by activating autophagy and improving mitochondrial function in Drosophila
Author(s) -
Xiaohui Lin,
Xin Wen,
Zaiwa Wei,
Keyi Guo,
Fang Shi,
Tingting Huang,
Wenjing Wang,
Jinou Zheng
Publication year - 2021
Publication title -
neuroreport/neuroreport
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.607
H-Index - 188
eISSN - 1473-558X
pISSN - 0959-4965
DOI - 10.1097/wnr.0000000000001599
Subject(s) - autophagy , neurodegeneration , neurotoxicity , downregulation and upregulation , western blot , mitochondrion , biology , medicine , endocrinology , neuroprotection , alzheimer's disease , disease , microbiology and biotechnology , toxicity , biochemistry , apoptosis , gene
Alzheimer disease is characterized by progressive decline in cognitive function due to neurodegeneration induced by accumulation of Aβ and hyperphosphorylated tau protein. This study was conducted to explore the protective effect of vitamin K2 against Aβ42-induced neurotoxicity.