Open AccessOverexpression of immunoproteasome low-molecular-mass polypeptide 7 and inhibiting role of next-generation proteasome inhibitor ONX 0912 on cell growth in glioma
Author(s) -
Ling-Zhao Min,
Xianwei Zeng,
Bin Li,
Bei Tao,
Jingxue Shi,
Wenbo Zhang,
Qiuyang Sun,
Chaohui Jing,
Xiaoqiang Wang
Publication year - 2019
Publication title -
neuroreport/neuroreport
Language(s) - English
Resource type - Journals
eISSN - 1473-558X
pISSN - 0959-4965
DOI - 10.1097/wnr.0000000000001320
Subject(s) - glioma , western blot , immunohistochemistry , molecular mass , cancer research , astrocytoma , cell , microbiology and biotechnology , biology , chemistry , immunology , gene , biochemistry , enzyme
The aim of this study was to determine the expression level of immunoproteasome and its clinical significance in glioma preliminarily. Furthermore, we studied the function and molecular mechanism of proteasome inhibitor ONX 0912 on glioma cell.