Open AccessEEG Correlates of Delirium in Children and Young Adults With CD19-Directed CAR T Cell Treatment-Related Neurotoxicity
Author(s) -
Juliane Gust,
Colleen Annesley,
Rebecca Gardner,
Xiuhua Bozarth
Publication year - 2019
Publication title -
journal of clinical neurophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.657
H-Index - 99
eISSN - 1537-1603
pISSN - 0736-0258
DOI - 10.1097/wnp.0000000000000669
Subject(s) - ictal , electroencephalography , neurotoxicity , medicine , epilepsy , neuroscience , psychology , psychiatry , toxicity
EEG patterns in chimeric antigen receptor T cell treatment-associated neurotoxicity (immune effector cell-associated neurotoxicity syndrome) have not yet been systematically studied. We tested the hypothesis that EEG background abnormalities in immune effector cell-associated neurotoxicity syndrome correlate with clinical signs of neurotoxicity. In addition, we describe ictal and interictal EEG patterns to better understand the natural history of immune effector cell-associated neurotoxicity syndrome-associated seizures.