Open AccessClinical Course of Patients With Ophthalmoplegia Caused by Radiographically Detectable Brainstem Demyelination Occurring as a Clinically Isolated Demyelinating Syndrome
Author(s) -
John H. Pula,
Kyle Brock,
Jorge C. Kattah
Publication year - 2011
Publication title -
journal of neuro-ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.586
H-Index - 55
eISSN - 1536-5166
pISSN - 1070-8022
DOI - 10.1097/wno.0b013e31821a4851
Subject(s) - internuclear ophthalmoplegia , diplopia , medicine , multiple sclerosis , brainstem , neurology , demyelinating disease , presentation (obstetrics) , clinically isolated syndrome , pathology , radiology , pediatrics , surgery , psychiatry
Demyelinating brainstem lesions often causing ophthalmoplegia may occur as the first manifestation of a clinically isolated demyelinating syndrome (CIS). CIS could be the initial attack of clinically definite multiple sclerosis (CDMS) should a second symptomatic attack occur. We report a series of patients with ophthalmoplegia occurring as CIS and assess potential factors affecting the clinical course and final outcome.