Open AccessLeber's Hereditary Optic Neuropathy in Older Individuals Because of Increased Alcohol Consumption During the COVID-19 Pandemic
Author(s) -
Kirill Zaslavsky,
Edward Margolin
Publication year - 2021
Publication title -
journal of neuro-ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.586
H-Index - 55
eISSN - 1536-5166
pISSN - 1070-8022
DOI - 10.1097/wno.0000000000001333
Subject(s) - medicine , population , pandemic , leber's hereditary optic neuropathy , penetrance , covid-19 , pediatrics , optic neuropathy , ophthalmology , disease , environmental health , optic nerve , genetics , phenotype , biology , infectious disease (medical specialty) , gene
Leber's hereditary optic neuropathy (LHON) is a disorder affecting oxidative phosphorylation in mitochondria. A majority of affected patients are men of 15 to 35 years of age. Phenotypic penetrance of this condition is only 50% in man and 10% in women and increases if the cellular energy demands go up, with the most common risk factors being smoking and alcohol use.