Open AccessIntravitreal Triamcinolone Acetonide Injection in a Rodent Model of Anterior Ischemic Optic Neuropathy
Author(s) -
Luciano S. Pereira,
Marcos Pereira de Ávila,
Luciana Ximenes Salustiano,
Álcio Coutinho de Paula,
Emmanuel Arnhold,
Timothy J. McCulley
Publication year - 2018
Publication title -
journal of neuro-ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.586
H-Index - 55
eISSN - 1536-5166
pISSN - 1070-8022
DOI - 10.1097/wno.0000000000000639
Subject(s) - anterior ischemic optic neuropathy , triamcinolone acetonide , medicine , ophthalmology , placebo , saline , optic nerve , acetonide , optic neuropathy , rodent model , retinal , surgery , anesthesia , pathology , alternative medicine
The management of nonarteritic anterior ischemic optic neuropathy centers around prevention of second eye involvement, without a uniformly accepted therapy for the involved eye. Several researchers have assessed the benefit of steroids with conflicting results. This experimental study was designed to evaluate the efficacy of a single intravitreal triamcinolone acetonide injection (IVTA) in preserving retinal ganglion cells (RGCs) in a rodent model of anterior ischemic optic neuropathy (rAION).