Open AccessOptimal Intereye Difference Thresholds in Retinal Nerve Fiber Layer Thickness for Predicting a Unilateral Optic Nerve Lesion in Multiple Sclerosis
Author(s) -
Rachel Nolan,
Steven Galetta,
Teresa C. Frohman,
Elliot M. Frohman,
Peter A. Calabresi,
Carmen CastrilloViguera,
Diego Cadavid,
Laura J. Balcer
Publication year - 2018
Publication title -
journal of neuro-ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.586
H-Index - 55
eISSN - 1536-5166
pISSN - 1070-8022
DOI - 10.1097/wno.0000000000000629
Subject(s) - medicine , nerve fiber layer , ophthalmology , optic nerve , multiple sclerosis , lesion , optic neuritis , retinal , optical coherence tomography , surgery , psychiatry
The optic nerve is a frequent site for involvement in multiple sclerosis (MS). Optical coherence tomography (OCT) detects thinning of the retinal nerve fiber layer (RNFL) in eyes of patients with MS and in those meeting criteria for clinically or radiologically isolated demyelinating syndromes. Current international diagnostic criteria for MS do not include the optic nerve as an imaging lesion site despite the high prevalence of acute optic neuritis (ON), or occult optic neuropathy, among early MS and clinically isolated syndrome patients; as well as most MS patients over the course of the disease. We sought to determine optimal thresholds for intereye difference in peripapillary RNFL thickness that are most predictive of a unilateral optic nerve lesion.