Open AccessCognitive and Behavioral Changes in Patients Treated With Droxidopa for Neurogenic Orthostatic Hypotension: A Retrospective Review
Author(s) -
Katherine E McDonell,
Cyndya A. Shibao,
Italo Biaggioni,
Adam L. Hartman,
David Robertson,
Daniel O. Claassen
Publication year - 2019
Publication title -
cognitive and behavioral neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.364
H-Index - 66
eISSN - 1543-3641
pISSN - 1543-3633
DOI - 10.1097/wnn.0000000000000198
Subject(s) - irritability , orthostatic vital signs , medicine , cognition , anesthesia , psychology , psychiatry , blood pressure
Droxidopa is a norepinephrine precursor that improves symptoms of neurogenic orthostatic hypotension in conditions such as Parkinson disease, multiple system atrophy, and pure autonomic failure by inducing a pressor effect. Unlike other pressor agents, droxidopa crosses the blood-brain barrier; however, its central effects are, as of yet, uncharacterized.