Open AccessInterrogating large multiple sclerosis registries and databases: what information can be gained?
Author(s) -
María Trojano,
Tomáš Kalinčík,
Pietro Iaffaldano,
Maria Pia Amato
Publication year - 2022
Publication title -
current opinion in neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 119
eISSN - 1473-6551
pISSN - 1350-7540
DOI - 10.1097/wco.0000000000001057
Subject(s) - observational study , multiple sclerosis , medicine , disease , natural history , real world evidence , medline , intensive care medicine , real world data , data science , psychiatry , computer science , political science , law
Although substantial progress has been made in understanding the natural history of multiple sclerosis (MS) and the development of new therapies, many questions concerning disease behavior and therapeutics remain to be answered. Data generated from real-world observational studies, based on large MS registries and databases and analyzed with advanced statistical methods, are offering the scientific community answers to some of these questions that are otherwise difficult or impossible to address. This review focuses on observational studies published in the last 2 years designed to compare the effectiveness of escalation vs. induction treatment strategies, to assess the effectiveness of treatment in pediatric-onset and late-onset MS, and to identify the clinical phenotype of secondary progressive (SP)MS.