Open AccessSerotonergic therapy in epilepsy
Author(s) -
Frank Gilliam,
Hrvoje Hečimović,
Matthew S. Gentry
Publication year - 2021
Publication title -
current opinion in neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 119
eISSN - 1473-6551
pISSN - 1350-7540
DOI - 10.1097/wco.0000000000000901
Subject(s) - serotonergic , epilepsy , dravet syndrome , fenfluramine , medicine , serotonin , neuroscience , depression (economics) , seizure threshold , psychology , psychiatry , anticonvulsant , receptor , economics , macroeconomics
The serotonergic system is implicated in multiple aspects of epilepsy, including seizure susceptibility, sudden unexpected death in epilepsy (SUDEP), and comorbid depression. Despite the complexity of serotonin's effects on various neuronal networks, ongoing research provides considerable insight into the role of serotonin in human epilepsy. This review explores the potential roles of serotonergic therapies to improve clinical outcomes in epilepsy.