Open AccessMagnetic resonance spectroscopy of isocitrate dehydrogenase mutated gliomas: current knowledge on the neurochemical profile
Author(s) -
Francesca Branzoli,
Małgorzata Marjańska
Publication year - 2020
Publication title -
current opinion in neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 119
eISSN - 1473-6551
pISSN - 1350-7540
DOI - 10.1097/wco.0000000000000833
Subject(s) - isocitrate dehydrogenase , neurochemical , glioma , in vivo magnetic resonance spectroscopy , medicine , idh1 , in vivo , ex vivo , glutamate receptor , metabolomics , cancer research , magnetic resonance imaging , bioinformatics , chemistry , biochemistry , biology , gene , mutation , enzyme , genetics , radiology , receptor
Magnetic resonance spectroscopy (MRS) may play a key role for the management of patients with glioma. We highlighted the utility of MRS in the noninvasive diagnosis of gliomas with mutations in isocitrate dehydrogenase (IDH) genes, by providing an overview of the neurochemical alterations observed in different glioma subtypes, as well as during treatment and progression, both in vivo and ex vivo.