Open AccessUpdate on T cells in the virally infected brain: friends and foes
Author(s) -
Shenjian Ai,
Robyn S. Klein
Publication year - 2020
Publication title -
current opinion in neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 119
eISSN - 1473-6551
pISSN - 1350-7540
DOI - 10.1097/wco.0000000000000825
Subject(s) - immunology , t cell , immune system , biology , immunopathology , immunotherapy , multiple sclerosis , central nervous system , medicine , neuroscience
The present review will outline neuroprotective and neurotoxic effects of central nervous system (CNS) infiltrating T cells during viral infections. Evidence demonstrating differential roles for antiviral effector and resident memory T-cell subsets in virologic control and immunopathology in the CNS will be discussed. Potential therapeutic targets emanating from a growing understanding of T-cell-initiated neuropathology that impacts learning and memory will also be delineated.