Open AccessChronic inflammation mediates brain injury in HIV infection: relevance for cure strategies
Author(s) -
Justin C. McArthur,
Tory P. Johnson
Publication year - 2020
Publication title -
current opinion in neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 119
eISSN - 1473-6551
pISSN - 1350-7540
DOI - 10.1097/wco.0000000000000807
Subject(s) - inflammation , neuroinflammation , medicine , immune system , immunology , microglia , systemic inflammation , central nervous system , endocrinology
Chronic inflammation is a major component of HIV infection, the effects of which can be devastating in the central nervous system (CNS). Protecting the brain is, therefore, critical as efforts proceed to cure HIV infection by reactivating latent viral reservoirs and driving immune responses. We review the clinical presentation and pathology findings of inflammatory processes in the CNS in patients managed with ART and the drivers of these processes.