Open AccessMolecular profiling of primary central nervous system lymphomas – predictive and prognostic value?
Author(s) -
Ka-wai Ho,
Christian Grommes
Publication year - 2019
Publication title -
current opinion in neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 119
eISSN - 1473-6551
pISSN - 1350-7540
DOI - 10.1097/wco.0000000000000759
Subject(s) - primary central nervous system lymphoma , lymphoma , medicine , diffuse large b cell lymphoma , oncology , immunohistochemistry , gene expression profiling , pathology , disease , cancer research , gene , biology , gene expression , biochemistry
Primary central nervous system lymphoma (PCNSL) is a rare but aggressive variant of non-Hodgkin lymphoma. The diagnostic gold standard remains the pathologic review of tumor tissue mainly collected though biopsies. The majority of PCNSL are diffuse large B cell lymphoma (DLBCL). Biopsies are invasive procedures, and there have been efforts to develop minimally invasive diagnostic testing using serum and cerebral spinal fluid. This article reviews multiple markers that could potentially serve as future diagnostic tools and predictors of treatment response.