Open AccessImmunological signatures in frontotemporal lobar degeneration
Author(s) -
Daniel W. Sirkis,
Luke W. Bonham,
Celeste M. Karch,
Jennifer S. Yokoyama
Publication year - 2019
Publication title -
current opinion in neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 119
eISSN - 1473-6551
pISSN - 1350-7540
DOI - 10.1097/wco.0000000000000665
Subject(s) - frontotemporal dementia , frontotemporal lobar degeneration , microglia , trem2 , neuroscience , immune system , biology , disease , medicine , dementia , inflammation , immunology , pathology
Over the last year, research into the immunological and inflammatory signatures of frontotemporal lobar degeneration (FTLD) has accelerated greatly. Herein, we highlight recently proposed roles of brain-resident microglia as well as peripheral myeloid cells in frontotemporal dementia (FTD)-spectrum disorders.