Open AccessApolipoprotein E4 Moderates the Association Between Vascular Risk Factors and Brain Pathology
Author(s) -
Carolyn S. Kaufman,
Jill K. Morris,
Eric D. Vidoni,
Jeffrey M. Burns,
Sandra A. Billinger
Publication year - 2021
Publication title -
alzheimer disease and associated disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 95
eISSN - 1546-4156
pISSN - 0893-0341
DOI - 10.1097/wad.0000000000000442
Subject(s) - apolipoprotein e , medicine , vascular disease , cardiology , risk factor , alzheimer's disease , pathogenesis , cholesterol , pathology , endocrinology , disease
The strongest genetic risk factor for late-onset Alzheimer disease (AD), Apolipoprotein E4 (APOE4), increases cardiovascular disease risk and may also act synergistically with vascular risk factors to contribute to AD pathogenesis. Here, we assess the interaction between APOE4 and vascular risk on cerebrovascular dysfunction and brain pathology.