Open AccessValidity of the Mini-Mental State Examination-2 in Diagnosing Mild Cognitive Impairment and Dementia in Patients Visiting an Outpatient Clinic in the Netherlands
Author(s) -
Daan K L Sleutjes,
Iris J Harmsen,
Floor S. van Bergen,
Joukje M. Oosterman,
Paul L. J. Dautzenberg,
Roy P.C. Kessels
Publication year - 2020
Publication title -
alzheimer disease and associated disorders
Language(s) - English
Resource type - Journals
eISSN - 1546-4156
pISSN - 0893-0341
DOI - 10.1097/wad.0000000000000403
Subject(s) - dementia , discriminative model , cognitive impairment , audiology , mini–mental state examination , outpatient clinic , cognition , receiver operating characteristic , psychology , psychiatry , medicine , gerontology , artificial intelligence , disease , computer science
This study examined the utility of the recently published MMSE-2:SV in detecting cognitive impairment. We used receiver operating characteristics to test the discriminative power of the MMSE-2:SV for distinguishing between older adults without mild cognitive impairment (MCI) or dementia (n=67) and patients with MCI (n=76) or dementia (n=79). The results show that the MMSE-2:SV had excellent discriminative ability in distinguishing older controls from patients with dementia, with cut-off scores of 26 and 27 (max=30) yielding appropriate sensitivity (0.810 and 0.924, respectively) and specificity (0.940 and 0.806). Discriminative power was close to good in distinguishing between older controls and patients with MCI. Here, however, no optimal cut-off point could be determined. Even though this study shows good sensitivity and adequate specificity for the MMSE-2:SV in discriminating individuals without MCI or dementia from those with dementia, its validity is limited for identifying patients with MCI.