Open AccessPhysical Exercise and Longitudinal Trajectories in Alzheimer Disease Biomarkers and Cognitive Functioning
Author(s) -
Marta Stojanovic,
Yuxuan Jin,
Anne M. Fagan,
Tammie L.S. Benzinger,
Jason Hassenstab,
Carlos Cruchaga,
John C. Morris,
Denise Head
Publication year - 2020
Publication title -
alzheimer disease and associated disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 95
eISSN - 1546-4156
pISSN - 0893-0341
DOI - 10.1097/wad.0000000000000385
Subject(s) - psychology , cognitive decline , cognition , neuropsychology , longitudinal study , episodic memory , cognitive reserve , physical exercise , verbal fluency test , biomarker , effects of sleep deprivation on cognitive performance , cognitive skill , disease , medicine , physical medicine and rehabilitation , dementia , neuroscience , pathology , cognitive impairment , biochemistry , chemistry
Associations of physical exercise with Alzheimer disease (AD) biomarkers and cognitive functioning have been observed cross-sectionally. However, the effects of exercise on longitudinal change in AD biomarkers have not been thoroughly investigated. The current study examined whether individuals with higher baseline exercise exhibited less longitudinal change in AD biomarkers and cognitive functioning, and whether APOE and/or brain-derived neurotrophic factor (BDNF) genotypes moderated the effects of exercise on longitudinal changes.