Open AccessComparative Performance and Neuropathologic Validation of the AD8 Dementia Screening Instrument
Author(s) -
Gabriela M. Morris,
Timothy R. Holden,
Hua Weng,
Chengjie Xiong,
Dean W. Coble,
Nigel J. Cairns,
John C. Morris
Publication year - 2019
Publication title -
alzheimer disease and associated disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 95
eISSN - 1546-4156
pISSN - 0893-0341
DOI - 10.1097/wad.0000000000000362
Subject(s) - dementia , alzheimer's disease , psychology , gold standard (test) , cohort , predictive validity , cohort study , medicine , psychiatry , clinical psychology , disease
The AD8 informant-based screening instrument has been validated with molecular biomarkers of Alzheimer disease (AD) but not with the gold standard of neuropathologic AD. The objective of this study was to validate the AD8 with neuropathologic AD and compare its predictive performance with that of the Mini-Mental State Examination and both participant-derived and informant-derived subjective memory complaint (SMC) regarding the participant.