Open AccessAnti-CD28 Antibody-Initiated Cytokine Storm in Canines
Author(s) -
Steven L. Rosinski,
Rainer Storb,
Roland K. Strong,
George E. Sale,
Diane Stone,
Mesfin Gewe,
Della Friend,
V. Kraig Abrams,
Julie RandolphHabecker,
Scott S. Graves
Publication year - 2015
Publication title -
transplantation direct
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.648
H-Index - 9
ISSN - 2373-8731
DOI - 10.1097/txd.0000000000000516
Subject(s) - medicine , cytokine storm , cytokine , cd28 , monoclonal antibody , antibody , transplantation , immunology , pharmacology , immune system , t cell , disease , covid-19 , infectious disease (medical specialty)
CD28 signal blockade following T cell receptor activation is under intense investigation as a tolerance-inducing therapy for transplantation. Our goal is to produce a CD28-specific reagent as a therapy for the prevention of graft rejection and graft-versus-host disease in the canine model of allogeneic hematopoietic cell transplantation (HCT).