Open AccessRapamycin Enhances Long-Term Hematopoietic Reconstitution of Ex Vivo Expanded Mouse Hematopoietic Stem Cells by Inhibiting Senescence
Author(s) -
Yi Luo,
Lei Li,
Ping Zou,
Jie Wang,
Longquan Shao,
Daohong Zhou,
Lingbo Liu
Publication year - 2014
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3182a7fcf8
Subject(s) - ex vivo , pi3k/akt/mtor pathway , haematopoiesis , stem cell , biology , microbiology and biotechnology , hematopoietic stem cell , bone marrow , senescence , transplantation , cancer research , immunology , in vivo , signal transduction , medicine , genetics
The mammalian target of rapamycin (mTOR) is an important regulator of hematopoietic stem cell (HSC) self-renewal and its overactivation contributes to HSC premature exhaustion in part via induction of HSC senescence. Inhibition of mTOR with rapamycin has the potential to promote long-term hematopoiesis of ex vivo expanded HSCs to facilitate the clinical application of HSC transplantation for various hematologic diseases.