Open AccessSAHA, an HDAC Inhibitor, Attenuates Antibody-Mediated Allograft Rejection
Author(s) -
Xin Zhang,
Meng Guo,
Yindong Kang,
Fang Liu,
Xueyang Zheng,
Shu Han,
Shangxi Fu,
Shanjuan Hong,
Guoyu Ding,
Liming Wang,
Quanxing Wang
Publication year - 2013
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31829b7bfc
Subject(s) - histone deacetylase inhibitor , viability assay , b cell , transplantation , antibody , secretion , apoptosis , histone deacetylase , cancer research , chemistry , immunology , biology , microbiology and biotechnology , medicine , histone , biochemistry , gene
Antibody-mediated rejection (AMR) is gaining increasing recognition as a critical causative factor contributing to graft loss in organ transplantation. However, current therapeutic options for prevention and treatment of AMR are very limited and ineffective. The impact of epigenetic modification in B-cell function and its involvement in AMR is still yet to be explored.