Inducible Costimulator (ICOS) Up-Regulation on Activated T Cells in Chronic Graft-Versus-Host Disease After Dog Leukocyte Antigen–Nonidentical Hematopoietic Cell Transplantation | Zendy

Masahiko Sato | Zendy; Rainer Storb | Zendy; Carol Loretz | Zendy; Diane Stone | Zendy; Marco Mielcarek | Zendy; George E. Sale | Zendy; Andrew R. Rezvani | Zendy; Scott S. Graves | Zendy

Open Access

Inducible Costimulator (ICOS) Up-Regulation on Activated T Cells in Chronic Graft-Versus-Host Disease After Dog Leukocyte Antigen–Nonidentical Hematopoietic Cell Transplantation

Author(s) -

Masahiko Sato,

Rainer Storb,

Carol Loretz,

Diane Stone,

Marco Mielcarek,

George E. Sale,

Andrew R. Rezvani,

Scott S. Graves

Publication year - 2013

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e318295c025

Subject(s) - cd28 , immunology , t cell , cd8 , transplantation , peripheral blood mononuclear cell , antigen , immune system , mixed lymphocyte reaction , monoclonal antibody , cd3 , medicine , antibody , biology , in vitro , biochemistry

Inducible costimulator (ICOS), a member of the CD28 family of costimulatory molecules, is induced on CD4 and CD8 T cells after their activation. ICOS functions as an essential immune regulator and ICOS blockade is a potential approach to immune modulation in allogeneic transplantation. Here, we describe the expression profile of ICOS in dogs and determine whether ICOS expression is up-regulated during chronic graft-versus-host disease (GVHD) and host-versus-graft reactions in the canine hematopoietic cell transplantation model.

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