Open AccessInducible Costimulator (ICOS) Up-Regulation on Activated T Cells in Chronic Graft-Versus-Host Disease After Dog Leukocyte Antigen–Nonidentical Hematopoietic Cell Transplantation
Author(s) -
Masahiko Sato,
Rainer Storb,
Carol Loretz,
Diane Stone,
Marco Mielcarek,
George E. Sale,
Andrew R. Rezvani,
Scott S. Graves
Publication year - 2013
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e318295c025
Subject(s) - cd28 , immunology , t cell , cd8 , transplantation , peripheral blood mononuclear cell , antigen , immune system , mixed lymphocyte reaction , monoclonal antibody , cd3 , medicine , antibody , biology , in vitro , biochemistry
Inducible costimulator (ICOS), a member of the CD28 family of costimulatory molecules, is induced on CD4 and CD8 T cells after their activation. ICOS functions as an essential immune regulator and ICOS blockade is a potential approach to immune modulation in allogeneic transplantation. Here, we describe the expression profile of ICOS in dogs and determine whether ICOS expression is up-regulated during chronic graft-versus-host disease (GVHD) and host-versus-graft reactions in the canine hematopoietic cell transplantation model.