Open AccessThe Seville Expert Workshop for Progress in Posttransplant Lymphoproliferative Disorders
Author(s) -
Denis Glotz,
Jeremy R. Chapman,
Vikas R. Dharnidharka,
Douglas W. Hanto,
Maria Cristina Ribeiro de Castro,
Hans H. Hirsch,
Véronique Leblond,
Aneesh K. Mehta,
AnneMarie Moulin,
Antonio Pagliuca,
Julio Pascual,
Alan B. Rickinson,
Francesco Paolo Russo,
Ralf Ulrich Trappe,
Angela C Webster,
Andreas Zuckermann,
Thomas G. Gross
Publication year - 2012
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e318269e64f
Subject(s) - immunosuppression , lymphoproliferative disorders , serostatus , medicine , intensive care medicine , multidisciplinary approach , immunology , lymphoma , human immunodeficiency virus (hiv) , viral load , social science , sociology
: Posttransplant lymphoproliferative disorders (PTLDs) are associated with significant morbidity and mortality among solid-organ transplant patients, but approaches to diagnosis and management vary considerably. An international multidisciplinary panel evaluated current understanding of risk factors and classification systems and developed recommendations to aid in PTLD prevention. We considered evidence on PTLD risk factors including Epstein-Barr virus serostatus and immunosuppression and identified knowledge gaps for future research. Recommendations address prophylactic and preemptive strategies to minimize PTLD development, including modulation of immunosuppression and antiviral drug regimens. Finally, new classification criteria were outlined that may help facilitate standardized reporting and improve our understanding of PTLD.