Cellular Infiltrates and NFκB Subunit c-Rel Signaling in Kidney Allografts of Patients With Clinical Operational Tolerance | Zendy

Luís Eduardo Becker | Zendy; Fúvia de Oliveira Biazotto | Zendy; Heike Conrad | Zendy; Matthias Schaier | Zendy; Lars Kihm | Zendy; Marie-Luise Groß-Weißmann | Zendy; Rüdiger Waldherr | Zendy; Angelika Bierhaus | Zendy; Peter P. Nawroth | Zendy; Martin Zeier | Zendy; Christian Morath | Zendy

Open Access

Cellular Infiltrates and NFκB Subunit c-Rel Signaling in Kidney Allografts of Patients With Clinical Operational Tolerance

Author(s) -

Luís Eduardo Becker,

Fúvia de Oliveira Biazotto,

Heike Conrad,

Matthias Schaier,

Lars Kihm,

Marie-Luise Groß-Weißmann,

Rüdiger Waldherr,

Angelika Bierhaus,

Peter P. Nawroth,

Martin Zeier,

Christian Morath

Publication year - 2012

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e31826032be

Subject(s) - immunohistochemistry , pathology , medicine , inflammation , kinase , microbiology and biotechnology , cancer research , biology , immunology

Nuclear factor kappa B (NFκB) plays a potential role in tolerance by orchestrating onset and resolution of inflammation and regulatory T cell differentiation through subunit c-Rel. We characterized cellular infiltrates and expression of NFκB1, c-Rel and its upstream regulators phosphatidylinositol 3-kinase/RAC-alpha serine/threonine kinase, in allograft biopsies from patients with spontaneous clinical operational tolerance (COT).

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