Open AccessCellular Infiltrates and NFκB Subunit c-Rel Signaling in Kidney Allografts of Patients With Clinical Operational Tolerance
Author(s) -
Luis Becker,
Fúvia de Oliveira Biazotto,
Heike Conrad,
Matthias Schaier,
Lars Kihm,
Marie-Luise Groß-Weißmann,
Rüdiger Waldherr,
Angelika Bierhaus,
Peter P. Nawroth,
Martin Zeier,
Christian Morath
Publication year - 2012
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31826032be
Subject(s) - immunohistochemistry , pathology , medicine , inflammation , kinase , microbiology and biotechnology , cancer research , biology , immunology
Nuclear factor kappa B (NFκB) plays a potential role in tolerance by orchestrating onset and resolution of inflammation and regulatory T cell differentiation through subunit c-Rel. We characterized cellular infiltrates and expression of NFκB1, c-Rel and its upstream regulators phosphatidylinositol 3-kinase/RAC-alpha serine/threonine kinase, in allograft biopsies from patients with spontaneous clinical operational tolerance (COT).