Open AccessNovel Approach for Improved Assessment of Phenotypic and Functional Characteristics of BKV-Specific T-Cell Immunity
Author(s) -
Hanna Trydzenskaya,
Arne Sattler,
Karin Müller,
Thomas Schachtner,
Chantip Dang-Heine,
Péter Friedrich,
Peter Nickel,
J. Hoerstrup,
Ralf Schindler,
Andreas Thiel,
Matthias F. Melzig,
Petra Reinke,
Nina Babel
Publication year - 2011
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e318234e0e5
Subject(s) - antigen , bk virus , biology , immunology , immunity , cd8 , cellular immunity , nephropathy , immune system , virology , tumor necrosis factor alpha , flow cytometry , t cell , kidney transplantation , kidney , diabetes mellitus , endocrinology
BKV-associated nephropathy represents a serious complication of the posttransplant period in kidney transplant recipients. Monitoring BKV-specific immunity is of a special importance for estimation of clinical course in patients with BKV reactivation. Our recent data demonstrated that all five BKV antigens are immunogenic and elicit T-cell responses varying within patients. Therefore, all five BKV proteins should be evaluated for the assessment of BKV-specific immunity. However, analysis of five proteins performed separately is time- and cost-intensive and requires large amount of blood.