Open AccessValidation of Urinary CXCL10 As a Marker of Borderline, Subclinical, and Clinical Tubulitis
Author(s) -
Julie Ho,
David Rush,
Martin Karpinski,
Leroy Storsley,
Ian W. Gibson,
Jennifer Bestland,
Ang Gao,
William P. Stefura,
Kent T. HayGlass,
Peter Nickerson
Publication year - 2011
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31822d4de1
Subject(s) - subclinical infection , medicine , urinary system , urology , area under the curve , interquartile range , creatinine , receiver operating characteristic , immunosuppression , urine , pathology
Renal allograft injury secondary to subclinical and clinical tubulitis remains an important cause of allograft fibrosis and loss despite modern immunosuppression. The goal of this study was to validate the previously reported use of urinary CXCL10 (interferon-γ-induced protein of 10 kDa) as a noninvasive marker of tubulitis in an independent clinical cohort.