Combined CD4 T-Cell and Antibody Response to Human Minor Histocompatibility Antigen DBY After Allogeneic Stem-Cell Transplantation | Zendy

Fabrice Porcheray | Zendy; David B. Miklos | Zendy; Blair H. Floyd | Zendy; Stefanie Sarantopoulos | Zendy; Roberto Bellucci | Zendy; Robert J. Soiffer | Zendy; Joseph H. Antin | Zendy; Edwin P. Alyea | Zendy; Jerome Ritz | Zendy; Emmanuel Zorn | Zendy

Open Access

Combined CD4 T-Cell and Antibody Response to Human Minor Histocompatibility Antigen DBY After Allogeneic Stem-Cell Transplantation

Author(s) -

Fabrice Porcheray,

David B. Miklos,

Blair H. Floyd,

Stefanie Sarantopoulos,

Roberto Bellucci,

Robert J. Soiffer,

Joseph H. Antin,

Edwin P. Alyea,

Jerome Ritz,

Emmanuel Zorn

Publication year - 2011

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e3182244cc3

Subject(s) - elispot , biology , antigen , immunology , t cell , transplantation , antibody , clone (java method) , stem cell , epitope , minor histocompatibility antigen , major histocompatibility complex , immune system , medicine , microbiology and biotechnology , genetics , dna

Antibody responses to HY antigens in male recipients are frequent after transplantation of stem cells from female donors (Miklos et al., Blood 2005; 105: 2973; Miklos et al., Blood 2004; 103: 353). However, evidence that this B-cell immunity is accompanied by T-cell responses to the cognate antigens is scarce. Here, we examined T- and B-cell responses to DBY antigen in a male patient who received hematopoietic stem cells from a human leukocyte antigen-identical female sibling.

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