Open AccessCombined CD4 T-Cell and Antibody Response to Human Minor Histocompatibility Antigen DBY After Allogeneic Stem-Cell Transplantation
Author(s) -
Fabrice Porcheray,
David B. Miklos,
Blair H. Floyd,
Stefanie Sarantopoulos,
Roberto Bellucci,
Robert J. Soiffer,
Joseph H. Antin,
Edwin P. Alyea,
Jérôme Ritz,
Emmanuel Zorn
Publication year - 2011
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3182244cc3
Subject(s) - elispot , biology , antigen , immunology , t cell , transplantation , antibody , clone (java method) , stem cell , epitope , minor histocompatibility antigen , major histocompatibility complex , immune system , medicine , microbiology and biotechnology , genetics , dna
Antibody responses to HY antigens in male recipients are frequent after transplantation of stem cells from female donors (Miklos et al., Blood 2005; 105: 2973; Miklos et al., Blood 2004; 103: 353). However, evidence that this B-cell immunity is accompanied by T-cell responses to the cognate antigens is scarce. Here, we examined T- and B-cell responses to DBY antigen in a male patient who received hematopoietic stem cells from a human leukocyte antigen-identical female sibling.