Open AccessMycophenolate and Tacrolimus for Graft-Versus-Host Disease Prophylaxis for Elderly After Cord Blood Transplantation: A Matched Pair Comparison With Tacrolimus Alone
Author(s) -
Naoyuki Uchida,
Atsushi Wake,
Nobuaki Nakano,
Kiichi Ishiwata,
Shinsuke Takagi,
Masatsugu Tsuji,
Hisashi Yamamoto,
Daisuke Kato,
Naofumi Matsuno,
Kazuhiro Masuoka,
Hideki Araoka,
Yuki AsanoMori,
Koji Izutsu,
Shigeyoshi Makino,
Akio Yoneyama,
Satoshi Taniguchi
Publication year - 2011
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e318223d7ac
Subject(s) - tacrolimus , medicine , cumulative incidence , calcineurin , graft versus host disease , incidence (geometry) , transplantation , mycophenolate , gastroenterology , umbilical cord , umbilical cord blood transplantation , surgery , immune system , immunology , urology , hematopoietic stem cell transplantation , physics , optics
The optimal graft-versus-host disease (GVHD) prophylaxis after umbilical cord blood transplantation has not been established. Our previous observation using single calcineurin inhibitors revealed a high incidence and severity of early immune-mediated complications, especially for older patients or those with poor performance status.