Luminex-Based Desensitization Protocols: The University of Wisconsin Initial Experience | Zendy

Silke V. Niederhaus | Zendy; Brenda Muth | Zendy; David Lorentzen | Zendy; Philip Y. Wai | Zendy; John D. Pirsch | Zendy; Milagros Samaniego | Zendy; Glen Leverson | Zendy; Anthony M. D’Alessandro | Zendy; Hans W. Sollinger | Zendy; Arjang Djamali | Zendy

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Luminex-Based Desensitization Protocols: The University of Wisconsin Initial Experience

Author(s) -

Silke V. Niederhaus,

Brenda Muth,

David Lorentzen,

Philip Y. Wai,

John D. Pirsch,

Milagros Samaniego,

Glen Leverson,

Anthony M. D’Alessandro,

Hans W. Sollinger,

Arjang Djamali

Publication year - 2011

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e31821c93bb

Subject(s) - thymoglobulin , medicine , kidney transplantation , panel reactive antibody , transplantation , plasmapheresis , gastroenterology , desensitization (medicine) , incidence (geometry) , kidney , urology , antibody , surgery , immunology , receptor , physics , optics

We have demonstrated that immunodominant donor-specific antibody (DSA) more than 100 mean fluorescence intensity (MFI) at the time of transplant is associated with a significantly higher risk of rejection. We now present short-term outcomes of DSA-based desensitization (DSZ) strategies in patients with a negative complement-dependent cytotoxicity crossmatch.

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