Open AccessCYP3A5 Genotype Does Not Influence Everolimus In Vitro Metabolism and Clinical Pharmacokinetics in Renal Transplant Recipients
Author(s) -
Nicolas Picard,
Koukeb Rouguieg-Malki,
Nassim Kamar,
Lionel Rostaing,
Pierre Marquet
Publication year - 2011
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31820ae4ac
Subject(s) - everolimus , pharmacokinetics , tacrolimus , pharmacology , cyp3a4 , pharmacogenetics , genotype , cyp3a5 , sirolimus , genotyping , medicine , biology , transplantation , metabolism , cytochrome p450 , biochemistry , gene
CYP3A5 genotyping might be useful to guide tacrolimus and sirolimus dosing. The aim of this study was to assess the influence of CYP3A5 polymorphism on everolimus metabolism and pharmacokinetics.
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