Open AccessImproving Long-Term Outcome in Allograft Transplantation: Role of Ionic Composition and Polyethylene Glycol
Author(s) -
Raphaël Thuillier,
Sébastien Giraud,
Frédéric Favreau,
Jean-Michel Goujon,
Thibault Desurmont,
Michel Eugène,
Benoı̂t Barrou,
Thierry Hauet
Publication year - 2011
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3182090fa3
Subject(s) - peg ratio , transplantation , polyethylene glycol , hydroxyethyl starch , immunosuppression , pegylation , medicine , chemistry , in vivo , andrology , immunology , surgery , biochemistry , biology , microbiology and biotechnology , finance , economics
Ischemia reperfusion injury (IRI) is inherent to transplantation, and correlates with negative outcome. Limiting IRI requires new preservation. Fourth generation solutions are emerging, using new colloid based on polyethylene glycol (PEG) polymers and extracellular ionic composition. We evaluated their eventual benefits for optimal resistance to IRI and improved outcome.