Allospecific Regulatory Effects of Sirolimus and Tacrolimus in the Human Mixed Lymphocyte Reaction | Zendy

Josh Levitsky | Zendy; Lorenzo Gallon | Zendy; Joshua Miller | Zendy; Anat R. Tambur | Zendy; Joseph R. Leventhal | Zendy; Catherine Flaa | Zendy; Xuemei Huang | Zendy; Bara Sarraj | Zendy; Wenge Wang | Zendy; James M. Mathew | Zendy

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Allospecific Regulatory Effects of Sirolimus and Tacrolimus in the Human Mixed Lymphocyte Reaction

Author(s) -

Josh Levitsky,

Lorenzo Gallon,

Joshua Miller,

Anat R. Tambur,

Joseph R. Leventhal,

Catherine Flaa,

Xuemei Huang,

Bara Sarraj,

Wenge Wang,

James M. Mathew

Publication year - 2011

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e318200e97

Subject(s) - mixed lymphocyte reaction , foxp3 , calcineurin , flow cytometry , tacrolimus , stimulation , lymphocyte , immunology , chemistry , transplantation , t cell , cancer research , biology , immune system , medicine , endocrinology

Tacrolimus (TAC) and sirolimus (SRL), two commonly used immunosuppressive agents, have demonstrated contrasting immunoregulatory effects. We recently described factors affecting the generation of allospecific CD4CD25 forkhead/winged helix transcription factor P3 (FOXP3) T-regulatory (Treg) cells in mixed lymphocyte reaction (Treg MLR) and now report additional findings on the effects of TAC and SRL.

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