Open AccessAllospecific Regulatory Effects of Sirolimus and Tacrolimus in the Human Mixed Lymphocyte Reaction
Author(s) -
Josh Levitsky,
Lorenzo Gallon,
Joshua Miller,
Anat R. Tambur,
Joseph R. Leventhal,
Catherine Flaa,
Xuemei Huang,
Bara Sarraj,
Edward Wang,
James M. Mathew
Publication year - 2011
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e318200e97
Subject(s) - mixed lymphocyte reaction , foxp3 , calcineurin , flow cytometry , tacrolimus , stimulation , lymphocyte , immunology , chemistry , transplantation , t cell , cancer research , biology , immune system , medicine , endocrinology
Tacrolimus (TAC) and sirolimus (SRL), two commonly used immunosuppressive agents, have demonstrated contrasting immunoregulatory effects. We recently described factors affecting the generation of allospecific CD4CD25 forkhead/winged helix transcription factor P3 (FOXP3) T-regulatory (Treg) cells in mixed lymphocyte reaction (Treg MLR) and now report additional findings on the effects of TAC and SRL.