Open AccessRegulatory T-Cell Generation and Kidney Allograft Tolerance Induced by Mesenchymal Stem Cells Associated With Indoleamine 2,3-Dioxygenase Expression
Author(s) -
Wei Ge,
Jifu Jiang,
Jacqueline Arp,
Weihua Liu,
Bertha García,
Hao Wang
Publication year - 2010
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181fed001
Subject(s) - indoleamine 2,3 dioxygenase , mesenchymal stem cell , foxp3 , immune tolerance , il 2 receptor , immunology , immunosuppression , medicine , kidney , in vivo , transplantation , spleen , kynurenine , regulatory t cell , t cell , cancer research , immune system , biology , endocrinology , pathology , tryptophan , biochemistry , microbiology and biotechnology , amino acid
The immunoregulatory properties of mesenchymal stem cells (MSCs) have been observed in vitro and in vivo. However, the underlying mechanisms of this immunomodulation remain undefined. Recent research demonstrated that MSCs express the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO), known to suppress T-cell responses. This study was designed to address whether MSCs induce kidney allograft tolerance and whether IDO contributes to the immunoregulatory functions of MSCs in vivo.