Open AccessDifferential Effect of Pretransplant Blood Transfusions on Immune Effector and Regulatory Compartments in HLA-Sensitized and Nonsensitized Recipients
Author(s) -
Michael Eikmans,
Marloes M. Waanders,
Dave L. Roelen,
Paula P.M.C. van Miert,
J. Anholts,
Hans W. de Fijter,
Anneke Brand,
Frans H.J. Claas
Publication year - 2010
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181fa943d
Subject(s) - immunology , immune system , human leukocyte antigen , foxp3 , il 2 receptor , interleukin 7 receptor , antibody , antigen , biology , medicine , t cell
Blood transfusion (BT) may elicit both harmful and beneficial immune responses against a subsequent organ graft. Immune parameters of a single, non leukocyte-depleted BT were investigated in two groups: non-human leukocyte antigen (HLA)-sensitized recipients with a one-HLA-DR matched donor (protocolled BT [PBT]) and females with previous exposure to HLA alloantigens through pregnancy (donor-specific transfusion [DST]).