Differential Effect of Pretransplant Blood Transfusions on Immune Effector and Regulatory Compartments in HLA-Sensitized and Nonsensitized Recipients | Zendy

Michael Eikmans | Zendy; Marloes M. Waanders | Zendy; Dave L. Roelen | Zendy; Paula P.M.C. van Miert | Zendy; Jacqy Anholts | Zendy; Johan W. de Fijter | Zendy; Anneke Brand | Zendy; Frans H.J. Claas | Zendy

Open Access

Differential Effect of Pretransplant Blood Transfusions on Immune Effector and Regulatory Compartments in HLA-Sensitized and Nonsensitized Recipients

Author(s) -

Michael Eikmans,

Marloes M. Waanders,

Dave L. Roelen,

Paula P.M.C. van Miert,

Jacqy Anholts,

Johan W. de Fijter,

Anneke Brand,

Frans H.J. Claas

Publication year - 2010

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e3181fa943d

Subject(s) - immunology , immune system , human leukocyte antigen , foxp3 , il 2 receptor , interleukin 7 receptor , antibody , antigen , biology , medicine , t cell

Blood transfusion (BT) may elicit both harmful and beneficial immune responses against a subsequent organ graft. Immune parameters of a single, non leukocyte-depleted BT were investigated in two groups: non-human leukocyte antigen (HLA)-sensitized recipients with a one-HLA-DR matched donor (protocolled BT [PBT]) and females with previous exposure to HLA alloantigens through pregnancy (donor-specific transfusion [DST]).

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