Open AccessThe Protective Role of Host Toll-Like Receptor-4 in Acute Graft-Versus-Host Disease
Author(s) -
Takehito Imado,
Tsuyoshi Iwasaki,
S Kitano,
Atsushi Satake,
Takanori Kuroiwa,
Sachi Tsunemi,
Hajime Sano
Publication year - 2010
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181f86947
Subject(s) - graft versus host disease , immunology , lipopolysaccharide , graft vs host reaction , tumor necrosis factor alpha , receptor , apoptosis , pathogenesis , medicine , toll like receptor , biology , transplantation , immune system , innate immune system , bone marrow , biochemistry , bone marrow transplantation
Mutations in Toll-like receptor (TLR)-4 have been associated with the hyporesponsiveness of macrophages to lipopolysaccharide, possibly reducing the risk of acute graft-versus-host disease (GVHD). However, TLR-4 mutations may also increase the risk of intestinal damage and microbial infection, thereby accelerating acute GVHD.