Open AccessDecreased Percentage of CD4+FoxP3+ Cells in Bronchoalveolar Lavage From Lung Transplant Recipients Correlates With Development of Bronchiolitis Obliterans Syndrome
Author(s) -
Sangeeta Bhorade,
Hong Chen,
Luciana Molinero,
Chuanhong Liao,
Edward R. Garrity,
Wickii T. Vigneswaran,
Rebecca A. Shilling,
Anne I. Sperling,
Anita S. Chong,
MariaLuisa Alegre
Publication year - 2010
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181e8dabe
Subject(s) - bronchiolitis obliterans , bronchoalveolar lavage , foxp3 , medicine , lung transplantation , immunology , lung , bronchiolitis , immunosuppression , transplantation , immune system , virus
Lung transplantation, in patients with end-stage lung disease, is limited by chronic rejection, which occurs with an incidence and severity exceeding most other transplanted organs. Alloimmune responses play an important role in progression to chronic rejection that manifests as bronchiolitis obliterans syndrome (BOS), but no biomarker can currently predict the progression to BOS. Studies in animal models suggest that intragraft T regulatory cells (Tregs) are important in maintaining transplantation tolerance, and FoxP3 is the protoypic Treg marker.