Open AccessDistinct Requirements for Achievement of Allotolerance Versus Reversal of Autoimmunity via Nonmyeloablative Mixed Chimerism Induction in NOD Mice
Author(s) -
Boris Nikolic,
Takashi Onoe,
Yasuo Takeuchi,
Zain Khalpey,
Valeria Primo,
Igor Leykin,
Rex Neal Smith,
Megan Sykes
Publication year - 2010
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181c4692e
Subject(s) - nod , autoimmunity , immunology , nod mice , medicine , immune system , endocrinology , diabetes mellitus
Mixed hematopoietic chimerism is associated with islet allograft tolerance and may reverse autoimmunity. We developed low intensity regimens for the induction of mixed chimerism and examined the effects on autoimmunity in prediabetic nonobese diabetic (NOD) mice.