Open AccessBone Marrow-Derived Cells Promote Liver Regeneration in Mice With Erythropoietic Protoporphyria
Author(s) -
María GarcíaBravo,
María-Josefa Morán-Jiménez,
Óscar Quintana-Bustamante,
Manuel Méndez,
Inmaculada Gutiérrez-Vera,
Juan A. Bueren,
Eduardo Salido,
José C. Segovia,
Antonio Fontanellas,
Rafael Enrı́quez de Salamanca
Publication year - 2009
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181bce00e
Subject(s) - bone marrow , pathology , transplantation , biology , medicine
Bone marrow transplantation can reverse hepatic protoporphyrin accumulation and prevent the hepatobiliary complications characteristic of erythropoietic protoporphyria. The aim of this study was to assess the recruitment capacity of bone marrow cells in the damaged liver and their possible contribution to the improved or recovered hepatic function in a murine model of erythropoietic protoporphyria (EPP).