Open AccessMycophenolic Acid Impedes the Antigen Presenting and Lymph Node Homing Capacities of Human Blood Myeloid Dendritic Cells
Author(s) -
Vito R. Cicinnati,
Jun Hou,
Monika Lindemann,
Peter A. Horn,
Georgios C. Sotiropoulos,
Andreas Paul,
Guido Gerken,
Susanne Beckebaum
Publication year - 2009
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181b0e608
Subject(s) - immunology , chemokine , population , peripheral blood mononuclear cell , cd86 , immune system , dendritic cell , biology , mycophenolate , homing (biology) , priming (agriculture) , chemokine receptor , lymphocyte , t cell , transplantation , medicine , in vitro , biochemistry , ecology , botany , germination , environmental health
Mycophenolic acid (MPA) is the pharmacologically active compound of the immunosuppressive drug mycophenolate mofetil. Dendritic cells (DC) are the key to initiating and priming the adaptive immune response leading to allograft rejection. We investigated the effects of MPA on human blood myeloid DC (MDC) homeostasis with a particular emphasis on their trafficking properties.