Open AccessBone Repair by Transplantation of hTERT-Immortalized Human Mesenchymal Stem Cells in Mice
Author(s) -
Hiroyuki Nakahara,
Haruo Misawa,
Tetsuo Hayashi,
Eisaku Kondo,
Takeshi Yuasa,
Yasuhiro Kubota,
Masayuki Seita,
Heizan Kawamoto,
Wael A. R. A. Hassan,
Reham Hassan,
Shahid M. Javed,
Masato Tanaka,
Hidenori Endo,
Hirofumi Noguchi,
Shinichi Matsumoto,
Katsuyoshi Takata,
Yuichi Tashiro,
Shuhei Nakaji,
Toshifumi Ozaki,
Naoya Kobayashi
Publication year - 2009
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181ae5ba2
Subject(s) - mesenchymal stem cell , telomerase reverse transcriptase , osteocalcin , microbiology and biotechnology , transplantation , stem cell , biology , telomerase , cancer research , alkaline phosphatase , immunology , medicine , genetics , biochemistry , gene , enzyme
Human mesenchymal stem cells (hMSCs) are multipotent stem cells found in the adult bone marrow that have the capacity to differentiate into various mesenchymal cell types. The hMSCs may provide a potential therapy to restore damaged tissues or organs of mesenchymal origin; however, a drawback is their limited life span in vitro.