Open AccessPirfenidone Inhibits T-Cell Activation, Proliferation, Cytokine and Chemokine Production, and Host Alloresponses
Author(s) -
Gary Visner,
Fengzhi Liu,
Peyman Bizargity,
Hanzhong Liu,
Kaifeng Liu,
Jun Yang,
Liqing Wang,
Wayne W. Hancock
Publication year - 2009
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181ae3392
Subject(s) - pirfenidone , cytokine , t cell , in vivo , immune system , chemokine , il 2 receptor , immunology , cd8 , adoptive cell transfer , pharmacology , cancer research , medicine , biology , lung , idiopathic pulmonary fibrosis , microbiology and biotechnology
We previously showed that pirfenidone, an anti-fibrotic agent, reduces lung allograft injury or rejection. In this study, we tested the hypothesis that pirfenidone has immune modulating activities and evaluated its effects on the function of T-cell subsets, which play important roles in allograft rejection.