Open AccessInvolvement of Platelet Activation by P2Y12 Receptor in the Development of Transplant Arteriosclerosis in Mice
Author(s) -
Kenichi Yashiro,
Yuji Matsumoto,
Hayato Ihara,
Yasuhiro Suzuki,
Kazunao Kondo,
Tetsumei Urano,
Kazuo Umemura
Publication year - 2009
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e318196305a
Subject(s) - p2y12 , arteriosclerosis , platelet activation , platelet , receptor , medicine , immunology , platelet aggregation
Although activated platelets influence inflammation by intraplatelet mediators in transplantation, their mechanism of involvement in the progression of transplant arteriosclerosis has not yet been elucidated. We, therefore, investigated this question using P2Y12 receptor knockout (KO) mice, in which platelets cannot be aggregated by adenosine diphosphate stimulation.